Bupropion (All indications except smoking cessation) updated on 07-01-2025

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18134
R76229		 Jackson, 2024 Post-partum hemorrhage (ICD-10 diagnosis code for PPH and a procedure code for blood transfusion) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.51 [0.25;4.95] 2/55   3,129/107,051 3,131 55
ref
S11736
R43092		 Palmsten b, 2013 Postpartum hemorrhage (ICD-9 code for 666.x) late pregnancy retrospective cohort (claims database) unexposed, sick Adjustment: Yes Indications Bupropion: Depression, mood or anxiety disorders Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified 1.32 [0.98;1.79] 42/1,162   1,896/69,044 1,938 1,162
ref
Total 2 studies 1.33 [0.99;1.78] 5,069 1,217
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jackson, 2024Jackson, 2024 1.51[0.25; 4.95]3,131554%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Palmsten b, 2013Palmsten b, 2013 1.32[0.98; 1.79]1,9381,16296%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.33[0.99; 1.78]5,0691,2170.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.99; 1.78]5,0691,2170%NAJackson, 2024 Palmsten b, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.51[0.34; 6.72]3,13155 -NAJackson, 2024 1 unexposed, sickunexposed, sick 1.32[0.98; 1.78]1,9381,162 -NAPalmsten b, 2013 1 Tags Adjustment   - Yes  - Yes 1.33[0.99; 1.78]5,0691,2170%NAJackson, 2024 Palmsten b, 2013 2 Indications Bupropion   - Depression, mood or anxiety disorders  - Depression, mood or anxiety disorders 1.32[0.98; 1.78]1,9381,162 -NAPalmsten b, 2013 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.32[0.98; 1.78]1,9381,162 -NAPalmsten b, 2013 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.51[0.34; 6.72]3,13155 -NAJackson, 2024 1 Unexposed sick   - old history of illness/treatment (> ...  - old history of illness/treatment (> 12 months before pregnancy) or not specified 1.32[0.98; 1.78]1,9381,162 -NAPalmsten b, 2013 1 All studiesAll studies 1.33[0.99; 1.78]5,0691,2170%NAJackson, 2024 Palmsten b, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.51[0.34; 6.72]3,13155 -NAJackson, 2024 1 unexposed, sick controlsunexposed, sick controls 1.32[0.98; 1.78]1,9381,162 -NAPalmsten b, 2013 10.510.01.0