Bupropion (All indications except smoking cessation) updated on 07-01-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13149
R50205		 Marks (Controls exposed to Sertraline), 2021 Preterm Birth during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.05 [0.77;1.43] C 61/406   238/1,653 299 406
ref
S11786
R43362		 Ozturk, 2016 Preterm Births (<37 weeks) at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 27.94 [0.52;1494.23] C 0/1   8/246 8 1
ref
Total 2 studies 2.90 [0.15;56.70] 307 407
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks (Controls exposed to Sertraline), 2021Marks, 2021 1 1.05[0.77; 1.43]29940669%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Ozturk, 2016Ozturk, 2016 27.94[0.52; 1494.23]8131%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 61% 2.90[0.15; 56.70]3074070.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Sertraline;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.90[0.15; 56.70]30740761%NAMarks (Controls exposed to Sertraline), 2021 Ozturk, 2016 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 27.94[0.52; 1494.23]81 -NAOzturk, 2016 1 exposed to other treatment, sickexposed to other treatment, sick 1.05[0.77; 1.43]299406 -NAMarks (Controls exposed to Sertraline), 2021 1 Tags Adjustment   - No  - No 2.90[0.15; 56.70]30740761%NAMarks (Controls exposed to Sertraline), 2021 Ozturk, 2016 2 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 2.90[0.15; 56.70]30740761%NAMarks (Controls exposed to Sertraline), 2021 Ozturk, 2016 2 Monotherapy   - no or not specified  - no or not specified 27.94[0.52; 1494.23]81 -NAOzturk, 2016 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.05[0.77; 1.43]299406 -NAMarks (Controls exposed to Sertraline), 2021 1 All studiesAll studies 2.90[0.15; 56.70]30740761%NAMarks (Controls exposed to Sertraline), 2021 Ozturk, 2016 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale27.94[0.52; 1494.23]81 -NAOzturk, 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.05[0.77; 1.43]299406 -NAMarks (Controls exposed to Sertraline), 2021 10.510.01.0