Bupropion (All indications except smoking cessation) updated on 07-01-2025

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12927
R49048		 Anderson, 2020 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.09 [0.43;2.77] -/-   0/- - -
ref
S12943
R49127		 Louik, 2014 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.47 [0.03;7.77] C 0/19   471/9,063 471 19
ref
Total 2 studies 1.00 [0.41;2.43] 471 19
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.09[0.43; 2.77]--90%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2014Louik, 2014 0.47[0.03; 7.77]4711910%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.00[0.41; 2.43]471190.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.00[0.41; 2.43]471190%NAAnderson, 2020 Louik, 2014 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.41; 2.43]471190%NAAnderson, 2020 Louik, 2014 2 Tags Adjustment   - No  - No 0.47[0.03; 7.77]47119 -NALouik, 2014 1   - Yes  - Yes 1.09[0.43; 2.77]-- -NAAnderson, 2020 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 1.00[0.41; 2.43]471190%NAAnderson, 2020 Louik, 2014 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.00[0.41; 2.43]471190%NAAnderson, 2020 Louik, 2014 2 All studiesAll studies 1.00[0.41; 2.43]471190%NAAnderson, 2020 Louik, 2014 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.00[0.41; 2.43]471190%NAAnderson, 2020 Louik, 2014 20.510.01.0