Bupropion (All indications except smoking cessation) updated on 07-01-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13087
R49623		 Chun-Fai-Chan (Controls exposed to other antidepressants), 2005 Therapeutic abortion at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Indications Bupropion: Depression, mood or anxiety disorders Matched Monotherapy: no or not specified 1.67 [0.39;7.19] C
excluded (control group) 		5/91   3/89 8 91
ref
S13088
R49628		 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Therapeutic abortion at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Matched Monotherapy: no or not specified 10.48 [1.32;83.03] C 10/136   1/133 11 136
ref
Total 1 studies 10.48 [1.32;83.03] 11 136
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chun-Fai-Chan (Controls unexposed, NOS), 2005Chun-Fai-Chan, 2005 1 10.48[1.32; 83.03]111360%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Tags Adjustment   - No  - No 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 MatchedMatched 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Monotherapy   - no or not specified  - no or not specified 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 All studiesAll studies 10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 13087

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.48[1.32; 83.03]11136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.67[0.39; 7.19]891 -NAChun-Fai-Chan (Controls exposed to other antidepressants), 2005 10.510.01.0