Bupropion (All indications except smoking cessation) updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11786
R43361		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 15.84 [0.30;825.45] C 0/1   15/261 15 1
ref
S13082
R49565		 Kjaersgaard, 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 1.53 [1.12;2.08] -/-   -/983,258 - -
ref
S13087
R49622		 Chun-Fai-Chan (Controls exposed to other antidepressants), 2005 Spontaneous abortion at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Indications Bupropion: Depression, mood or anxiety disorders Matched Monotherapy: no or not specified 1.29 [0.55;3.02] C
excluded (control group) 		14/91   11/89 25 91
ref
S13088
R49627		 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Spontaneous abortion at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Matched Monotherapy: no or not specified 3.65 [1.42;9.40] C 20/136   6/133 26 136
ref
S11757
R43206		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 25.11 [0.47;1334.55] C 0/1   9/248 9 1
ref
Total 4 studies 2.63 [1.09;6.36] 50 138
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 15.84[0.30; 825.45]1515%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Kjaersgaard, 2013Kjaersgaard, 2013 1.53[1.12; 2.08]--56%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Chun-Fai-Chan (Controls unexposed, NOS), 2005Chun-Fai-Chan, 2005 1 3.65[1.42; 9.40]2613635%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yaris, 2005Yaris, 2005 25.11[0.47; 1334.55]915%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (4 studies) I2 = 49% 2.63[1.09; 6.36]501380.5100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 4 Tags Adjustment   - No  - No 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 4 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 4 MatchedMatched 3.65[1.42; 9.40]26136 -NAChun-Fai-Chan (Controls unexposed, NOS), 2005 1 Monotherapy   - no or not specified  - no or not specified 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 4 All studiesAll studies 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 40.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.85.72.4330.000Ozturk, 2016Kjaersgaard, 2013Chun-Fai-Chan (Controls unexposed, NOS), 2005Yaris, 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 13087

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.63[1.09; 6.36]5013849%NAOzturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.29[0.55; 3.02]2591 -NAChun-Fai-Chan (Controls exposed to other antidepressants), 2005 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Xing (Spontaneous abortion)Xing (Spontaneous abortion) 1.99[0.98; 4.02]60%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 2.63[1.09; 6.36]49%138----Ozturk, 2016 Kjaersgaard, 2013 Chun-Fai-Chan (Controls unexposed, NOS), 2005 Yaris, 2005 40.510.01.0