Bupropion (All indications except smoking cessation) updated on 07-01-2025

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12927
R49065		 Anderson, 2020 Any limb deficiency 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.90 [0.32;2.50] -/-   0/- - -
ref
S12933
R49093		 Cole, 2007 Musculoskeletal malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 1.68 [0.43;6.50] C 3/1,213   7/4,743 10 1,213
ref
Total 2 studies 1.13 [0.50;2.56] 10 1,213
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.90[0.32; 2.50]--63%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Cole, 2007Cole, 2007 1.68[0.43; 6.50]101,21337%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.13[0.50; 2.56]101,2130.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.68[0.43; 6.50]101,213 -NACole, 2007 1 case control studiescase control studies 0.90[0.32; 2.52]-- -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.32; 2.52]-- -NAAnderson, 2020 1 exposed to other treatment, sickexposed to other treatment, sick 1.68[0.43; 6.50]101,213 -NACole, 2007 1 Tags Adjustment   - No  - No 1.68[0.43; 6.50]101,213 -NACole, 2007 1   - Yes  - Yes 0.90[0.32; 2.52]-- -NAAnderson, 2020 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 1.13[0.50; 2.56]101,2130%NAAnderson, 2020 Cole, 2007 2 Monotherapy   - no or not specified  - no or not specified 1.68[0.43; 6.50]101,213 -NACole, 2007 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.90[0.32; 2.52]-- -NAAnderson, 2020 1 All studiesAll studies 1.13[0.50; 2.56]101,2130%NAAnderson, 2020 Cole, 2007 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.32; 2.52]-- -NAAnderson, 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.68[0.43; 6.50]101,213 -NACole, 2007 10.510.01.0