metaPreg - Chlordiazepoxide during pregnancy

Chlordiazepoxide updated on 02-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.18 [0.82, 1.70]	48%	5 studies	161,237	738	not evaluable	ROB	-
Major congenital malformations	1.47 [1.14, 1.89]	0%	4 studies	158,496	476	not evaluable	ROB	2.30 [1.54; .]
Congenital heart defects	1.75 [0.91, 3.39]	41%	3 studies	83,986	389	not evaluable	ROB	-
Cleft lip with or without cleft palate	1.12 [0.33, 3.81]	0%	2 studies	630	6	not evaluable	ROB	-
Cleft palate	2.01 [0.18, 22.38]	-	1 study	179	3	not evaluable	ROB	-
Ano-rectal atresia and stenosis	3.00 [0.11, 81.44]	-	1 study			not evaluable	ROB	-
Club foot / Talipes equinovarus	1.00 [0.30, 3.37]	-	1 study			not evaluable	ROB	-
Ear malformations	0.60 [0.07, 4.95]	-	1 study			not evaluable	ROB	-
Hydrocephaly	3.00 [0.11, 81.44]	-	1 study			not evaluable	ROB	-
Hypospadias	2.20 [0.71, 6.81]	-	1 study			not evaluable	ROB	-
Limb reduction defects (LRD)	-	-	0 study					-
Minor congenital malformations	0.55 [0.22, 1.36]	-	1 study	551	87	not evaluable	ROB	-
Neural Tube Defects	3.00 [0.31, 29.29]	-	1 study			not evaluable	ROB	-
Oesophageal atresia with or without tracheo-oesophageal fistula	7.00 [0.38, 128.84]	-	1 study			not evaluable	ROB	-
Polydactyly	1.20 [0.29, 4.95]	-	1 study			not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.04 [0.83, 1.31]	-	1 study	224,428	934	not evaluable	ROB	-
Small for gestational age (weight)	1.22 [0.99, 1.50]	-	1 study	261,229	943	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks) / Stillbirths	1.12 [0.65, 1.90]	0%	2 studies	26,794	1,129	not evaluable	ROB	-
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.42 [0.38, 5.36]	29%	2 studies	27,200	193	not evaluable	ROB	-
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