Chlordiazepoxide updated on 02-10-2025

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15450
R63551		 Czeizel, 2004 Ear congenital anomalies 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched 0.60 [0.10;6.80] -/-   360/- - -
ref
Total 1 studies 0.60 [0.07;4.95] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Czeizel, 2004Czeizel, 2004 0.60[0.10; 6.80]--0%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: moderateROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.60[0.07; 4.95]-- -NACzeizel, 2004 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.60[0.07; 4.95]-- -NACzeizel, 2004 1 Tags Adjustment   - Yes  - Yes 0.60[0.07; 4.95]-- -NACzeizel, 2004 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 0.60[0.07; 4.95]-- -NACzeizel, 2004 1 MatchedMatched 0.60[0.07; 4.95]-- -NACzeizel, 2004 1 All studiesAll studies 0.60[0.07; 4.95]-- -NACzeizel, 2004 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.60[0.07; 4.95]351- -NACzeizel, 2004 10.510.01.0