Caftor updated on 01-21-2026

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Major congenital malformations0.72 [0.27, 1.93]-1 study26148not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.03 [0.74, 1.43]0%3 studies220273not evaluable ROB-
Extremely preterm (< 28 weeks)0.33 [0.02, 6.19]-1 study4147not evaluable ROB-
Large for gestational age (weight)1.22 [0.66, 2.26]-1 study56147not evaluable ROB-
Small for gestational age (weight)0.38 [0.19, 0.76]-1 study81147not evaluable ROB4.70 [.; 1.97]
Very preterm (28 to 32 weeks)2.28 [0.50, 10.29]-1 study7147not evaluable ROB-
Low birth weight (< 2500g)0.90 [0.43, 1.89]-1 study3967not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean0.89 [0.55, 1.45]0%2 studies149103not evaluable ROB-
Assisted deliveries (forceps, vacuum, ...)--0 study-
Gestational diabetes2.84 [1.87, 4.32]-1 study127148not evaluable ROB5.13 [3.15; .]
Preeclampsia1.19 [0.49, 2.92]-1 study25148not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neonatal medical care1.29 [0.68, 2.43]-1 study5675not evaluable ROB-
Low Apgar score (< 7) (at 1 min)0.70 [0.30, 1.65]-1 study2870not evaluable ROB-
Low Apgar score (< 7) (at 5 min)0.76 [0.18, 3.16]-1 study971not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Late intrauterine deaths (> 22 weeks) / Stillbirths0.61 [0.03, 12.74]-1 study2148not evaluable ROB-
Therapeutic terminations of pregnancy0.38 [0.05, 3.04]-1 study9148not evaluable ROB-
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions0.71 [0.33, 1.51]-1 study37101not evaluable ROB-

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