Caftor

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18836
R80239		 Chouchana (Controls unexposed, disease free), 2025 Very preterm birth 28–31 weeks at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 4.21 [1.34;13.22] C
excluded (control group) 		3/147   18,933/3,849,289 18,936 147
ref
S18835
R80223		 Chouchana (Controls unexposed, sick), 2025 Very preterm birth 28–31 weeks at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 2.28 [0.50;10.29] C 3/147   4/441 7 147
ref
Total 1 studies 2.28 [0.50;10.29] 7 147
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chouchana (Controls unexposed, sick), 2025Chouchana, 2025 1 2.28[0.50; 10.29]71470%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.28[0.50; 10.29]7147 -NAChouchana (Controls unexposed, sick), 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.28[0.50; 10.29]7147 -NAChouchana (Controls unexposed, sick), 2025 1 Tags Adjustment   - No  - No 2.28[0.50; 10.29]7147 -NAChouchana (Controls unexposed, sick), 2025 1 All studiesAll studies 2.28[0.50; 10.29]7147 -NAChouchana (Controls unexposed, sick), 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.21[1.34; 13.22]18,936147 -NAChouchana (Controls unexposed, disease free), 2025 1 unexposed, sick controlsunexposed, sick controls 2.28[0.50; 10.29]7147 -NAChouchana (Controls unexposed, sick), 2025 10.510.01.0