Caftor

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18836
R80230		 Chouchana (Controls unexposed, disease free), 2025 Gestational diabetes at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 2.88 [2.06;4.03] C
excluded (control group) 		53/148   629,089/3,879,601 629,142 148
ref
S18835
R80214		 Chouchana (Controls unexposed, sick), 2025 Gestational diabetes at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 2.84 [1.87;4.32] C 53/148   74/451 127 148
ref
S18863
R80333		 Etherington (ETI), 2024 Gestational diabetes mellitus (GDM) at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.89 [1.19;12.68] C 17/24   10/26 27 24
ref
Total 2 studies 2.94 [1.98;4.37] 154 172
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chouchana (Controls unexposed, sick), 2025Chouchana, 2025 1 2.84[1.87; 4.32]12714889%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Etherington (ETI), 2024Etherington, 2024 2 3.89[1.19; 12.68]272411%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: unclear Total (2 studies) I2 = 0% 2.94[1.98; 4.37]1541720.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: ETI;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.94[1.98; 4.37]1541720%NAChouchana (Controls unexposed, sick), 2025 Etherington (ETI), 2024 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.94[1.98; 4.37]1541720%NAChouchana (Controls unexposed, sick), 2025 Etherington (ETI), 2024 2 Tags Adjustment   - No  - No 2.94[1.98; 4.37]1541720%NAChouchana (Controls unexposed, sick), 2025 Etherington (ETI), 2024 2 All studiesAll studies 2.94[1.98; 4.37]1541720%NAChouchana (Controls unexposed, sick), 2025 Etherington (ETI), 2024 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.88[2.06; 4.03]629,142148 -NAChouchana (Controls unexposed, disease free), 2025 1 unexposed, sick controlsunexposed, sick controls 2.94[1.98; 4.37]1541720%NAChouchana (Controls unexposed, sick), 2025 Etherington (ETI), 2024 20.510.01.0