Caftor

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18836
R80244		 Chouchana (Controls unexposed, disease free), 2025 Large for gestational age (> 90th percentile) at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.13 [0.67;1.90] C
excluded (control group) 		16/147   374,671/3,849,289 374,687 147
ref
S18835
R80228		 Chouchana (Controls unexposed, sick), 2025 Large for gestational age (> 90th percentile) at least 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No 1.22 [0.66;2.26] C 16/147   40/441 56 147
ref
Total 1 studies 1.22 [0.66;2.26] 56 147
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chouchana (Controls unexposed, sick), 2025Chouchana, 2025 1 1.22[0.66; 2.26]561470%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.66; 2.26]56147 -NAChouchana (Controls unexposed, sick), 2025 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.22[0.66; 2.26]56147 -NAChouchana (Controls unexposed, sick), 2025 1 Tags Adjustment   - No  - No 1.22[0.66; 2.26]56147 -NAChouchana (Controls unexposed, sick), 2025 1 All studiesAll studies 1.22[0.66; 2.26]56147 -NAChouchana (Controls unexposed, sick), 2025 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.13[0.67; 1.90]374,687147 -NAChouchana (Controls unexposed, disease free), 2025 1 unexposed, sick controlsunexposed, sick controls 1.22[0.66; 2.26]56147 -NAChouchana (Controls unexposed, sick), 2025 10.510.01.0