Caftor

Assisted deliveries (forceps, vacuum, ...)

id	Study   Auto Chouchana (Controls unexposed, disease free), 2025Chouchana (Controls unexposed, sick), 2025	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18836 R80236	Chouchana (Controls unexposed, disease free), 2025	Assisted vaginal delivery	at least 1st trimester	retrospective cohort (claims database)	unexposed, disease free excluded	Adjustment: No	2.86 [2.01;4.08] C excluded (control group)	43/147   485,999/3,849,289	486,042	147		ref
S18835 R80220	Chouchana (Controls unexposed, sick), 2025	Assisted vaginal delivery	at least 1st trimester excluded	retrospective cohort (claims database)	unexposed, sick	Adjustment: No	2.58 [1.65;4.03] C excluded (exposition period)	43/147   61/441	104	147		ref
					Total	0 studies	NaN [NaN;NaN]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis