Caftor

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18834
R80212		 Salvatore, 2026 Cesarean deliveries throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 1.09 [0.52;2.25] C 24/42   54/98 78 42
ref
S18836
R80235		 Chouchana (Controls unexposed, disease free), 2025 Caesarean section at least 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 2.08 [1.48;2.92] C
excluded (control group) 		50/147   765,181/3,849,289 765,231 147
ref
S18835
R80219		 Chouchana (Controls unexposed, sick), 2025 Caesarean section at least 1st trimester excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 1.44 [0.97;2.16] C
excluded (exposition period) 		50/147   116/441 166 147
ref
S18837
R80247		 Jain, 2025 Cesarean section deliveries during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.76 [0.40;1.46] C 26/61   45/91 71 61
ref
Total 2 studies 0.89 [0.55;1.45] 149 103
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Salvatore, 2026Salvatore, 2026 1.09[0.52; 2.25]784244%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Jain, 2025Jain, 2025 0.76[0.40; 1.46]716156%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: criticalROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 0% 0.89[0.55; 1.45]1491030.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.55; 1.45]1491030%NASalvatore, 2026 Jain, 2025 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.89[0.55; 1.45]1491030%NASalvatore, 2026 Jain, 2025 2 Tags Adjustment   - No  - No 0.89[0.55; 1.45]1491030%NASalvatore, 2026 Jain, 2025 2 All studiesAll studies 0.89[0.55; 1.45]1491030%NASalvatore, 2026 Jain, 2025 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18836

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.89[0.55; 1.45]1491030%NASalvatore, 2026 Jain, 2025 20.510.01.0