metaPreg - Clotrimazole during pregnancy

Clotrimazole updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.04 [0.93, 1.17]	0%	3 studies	30,990	3,830	not evaluable	ROB	-
Cleft lip with or without cleft palate	0.86 [0.48, 1.54]	0%	3 studies	2,288	2,516	not evaluable	ROB	-
Congenital heart defects	0.94 [0.73, 1.20]	0%	3 studies	8,965	2,542	not evaluable	ROB	-
Gastroschisis	1.31 [0.21, 8.40]	0%	2 studies	658	508	not evaluable	ROB	-
Hypospadias	1.04 [0.66, 1.64]	0%	2 studies	3,171	541	not evaluable	ROB	-
Major congenital malformations	1.03 [0.88, 1.20]	29%	2 studies	24,426	2,744	not evaluable	ROB	-
Neural Tube Defects	0.92 [0.48, 1.78]	0%	2 studies	1,952	254	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	0.30 [0.11, 0.85]	-	1 study	109	45	not evaluable	ROB	6.12 [.; 1.64]
15 non statistically significant endpoints reported in only one study
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study