metaPreg - Itraconazole during pregnancy

Itraconazole updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.20 [0.83, 1.72]	0%	4 studies	25,231	1,094	not evaluable	ROB	-
Major congenital malformations	1.20 [0.83, 1.72]	0%	4 studies	25,231	1,094	not evaluable	ROB	-
5 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.44 [0.48, 4.35]	67%	2 studies	42	281	not evaluable	ROB	-
2 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	-	-	0 study					-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal disorders (as a whole)	0.80 [0.57, 1.11]	0%	2 studies	66	319	not evaluable	ROB	-
Low Apgar score (< 7) (at 1 min)	-	-	0 study					-
Low Apgar score (< 7) (at 5 min)	-	-	0 study					-
Very low Apgar score (< 5) (at 1 min)	-	-	0 study					-
Very low Apgar score (< 5) (at 5 min)	-	-	0 study					-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	2.11 [1.16, 3.82]	39%	3 studies	107	536	not evaluable	ROB	3.64 [1.60; .]
Elective/induced termination of pregnancy	5.29 [1.07, 26.22]	56%	2 studies	42	405	not evaluable	ROB	10.06 [1.34; .]
Late intrauterine deaths (> 22 weeks)	1.78 [0.37, 8.53]	0%	2 studies	6	405	not evaluable	ROB	-
Intrauterine deaths (as a whole or unspecified)	1.75 [1.47, 2.09]	-	1 study	54	199	not evaluable	ROB	2.90 [2.30; .]