Itraconazole

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Jick, 1999 Bar-Oz, 2000 De Santis, 2009 Molgaard-Nielsen, 2013 41.20[0.83; 1.72]25,2311,094not evaluable Major congenital malformations Jick, 1999 Bar-Oz, 2000 De Santis, 2009 Molgaard-Nielsen, 2013 41.20[0.83; 1.72]25,2311,094not evaluable Congenital heart defects Jick, 1999 13.73[0.43; 32.30]688not evaluable Limb defects Jick, 1999 12.33[0.29; 18.83]988not evaluable Oro-facial clefts Jick, 1999 16.20[0.25; 153.31]188not evaluable Polydactyly Jick, 1999 11.69[0.09; 30.75]588not evaluable Spina bifida Jick, 1999 13.72[0.18; 78.03]288not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Bar-Oz, 2000 De Santis, 2009 21.44[0.48; 4.35]42281not evaluable Low birth weight (< 2500g) De Santis, 2009 10.28[0.03; 2.56]5152not evaluable Macrosomia (> 4000g) De Santis, 2009 11.69[0.63; 4.55]17152not evaluable Maternal consequences Caesarean 0----- Neonatal disorders Neonatal disorders (as a whole) Bar-Oz, 2000 De Santis, 2009 20.80[0.57; 1.11]66319not evaluable Low Apgar score (< 7) (at 1 min) 0----- Low Apgar score (< 7) (at 5 min) 0----- Very low Apgar score (< 5) (at 1 min) 0----- Very low Apgar score (< 5) (at 5 min) 0----- Intrauterine deaths Early intrauterine death (< 22 weeks) Bar-Oz, 2000 De Santis, 2009 Molgaard-Nielsen (Controls unexposed, NOS), 2016 32.11[1.16; 3.82]107536not evaluable Elective/induced termination of pregnancy Bar-Oz, 2000 De Santis, 2009 25.29[1.07; 26.22]42405not evaluable Late intrauterine deaths (> 22 weeks) Bar-Oz, 2000 De Santis, 2009 21.78[0.37; 8.53]6405not evaluable Intrauterine deaths (as a whole or unspecified) Bar-Oz, 2000 11.75[1.47; 2.09]54199not evaluable0.0100.01.0

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