Itraconazole updated on 01-29-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17548
R73899		 De Santis, 2009 Termination of pregnancy (TOP) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 2.90 [1.19;7.06] C 19/206   7/207 26 206
ref
S17547
R73886		 Bar-Oz, 2000 Therapeutic abortions 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 16.06 [2.10;122.80] C 15/199   1/198 16 199
ref
Total 2 studies 5.29 [1.07;26.22] 42 405
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Santis, 2009De Santis, 2009 2.90[1.19; 7.06]2620665%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Bar-Oz, 2000Bar-Oz, 2000 16.06[2.10; 122.80]1619935%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 56% 5.29[1.07; 26.22]424050.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.29[1.07; 26.22]4240556%NADe Santis, 2009 Bar-Oz, 2000 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.29[1.07; 26.22]4240556%NADe Santis, 2009 Bar-Oz, 2000 2 Tags Adjustment   - No  - No 5.29[1.07; 26.22]4240556%NADe Santis, 2009 Bar-Oz, 2000 2 MatchedMatched 5.29[1.07; 26.22]4240556%NADe Santis, 2009 Bar-Oz, 2000 2 All studiesAll studies 5.29[1.07; 26.22]4240556%NADe Santis, 2009 Bar-Oz, 2000 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.29[1.07; 26.22]4240556%NADe Santis, 2009 Bar-Oz, 2000 20.510.01.0