Itraconazole updated on 01-29-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17548
R73902		 De Santis, 2009 Premature birth (NOS) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.85 [0.38;1.91] C 11/162   15/190 26 162
ref
S17547
R73890		 Bar-Oz, 2000 Preterm (NOS) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 2.63 [0.98;7.06] 10/119   6/188 16 119
ref
Total 2 studies 1.44 [0.48;4.35] 42 281
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Santis, 2009De Santis, 2009 0.85[0.38; 1.91]2616253%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Bar-Oz, 2000Bar-Oz, 2000 2.63[0.98; 7.06]1611947%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 67% 1.44[0.48; 4.35]422810.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.44[0.48; 4.35]4228167%NADe Santis, 2009 Bar-Oz, 2000 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.44[0.48; 4.35]4228167%NADe Santis, 2009 Bar-Oz, 2000 2 Tags Adjustment   - No  - No 1.44[0.48; 4.35]4228167%NADe Santis, 2009 Bar-Oz, 2000 2 MatchedMatched 1.44[0.48; 4.35]4228167%NADe Santis, 2009 Bar-Oz, 2000 2 All studiesAll studies 1.44[0.48; 4.35]4228167%NADe Santis, 2009 Bar-Oz, 2000 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.44[0.48; 4.35]4228167%NADe Santis, 2009 Bar-Oz, 2000 20.510.01.0