Itraconazole updated on 01-29-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17548
R73905		 De Santis, 2009 Neonatal complications 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.53 [0.10;2.94] C 2/163   4/175 6 163
ref
S17547
R73895		 Bar-Oz, 2000 Neonatal abnormalities 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.81 [0.58;1.15] 23/156   37/186 60 156
ref
Total 2 studies 0.80 [0.57;1.11] 66 319
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Santis, 2009De Santis, 2009 0.53[0.10; 2.94]61634%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Bar-Oz, 2000Bar-Oz, 2000 0.81[0.58; 1.15]6015696%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.80[0.57; 1.11]663190.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.57; 1.11]663190%NADe Santis, 2009 Bar-Oz, 2000 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.57; 1.11]663190%NADe Santis, 2009 Bar-Oz, 2000 2 Tags Adjustment   - No  - No 0.80[0.57; 1.11]663190%NADe Santis, 2009 Bar-Oz, 2000 2 MatchedMatched 0.80[0.57; 1.11]663190%NADe Santis, 2009 Bar-Oz, 2000 2 All studiesAll studies 0.80[0.57; 1.11]663190%NADe Santis, 2009 Bar-Oz, 2000 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.57; 1.11]663190%NADe Santis, 2009 Bar-Oz, 2000 20.510.01.0