Itraconazole updated on 01-29-2025

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17550
R73909		 Molgaard-Nielsen (Controls exposed to pivmecillinam), 2016 Spontaneous abortion (before week 22) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.13 [0.52;2.48] C
excluded (control group) 		7/131   143/3,018 150 131
ref
S17551
R73910		 Molgaard-Nielsen (Controls unexposed, NOS), 2016 Spontaneous abortion (before week 22) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Matched 1.16 [0.51;2.60] 7/131   34/524 41 131
ref
S17548
R73898		 De Santis, 2009 Spontaneous abortion 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 2.48 [1.15;5.34] C 23/206   10/207 33 206
ref
S17547
R73885		 Bar-Oz, 2000 Spontaneous abortion 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 3.25 [1.43;7.40] C 25/199   8/189 33 199
ref
Total 3 studies 2.11 [1.16;3.82] 107 536
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Molgaard-Nielsen (Controls unexposed, NOS), 2016Molgaard-Nielsen, 2016 1 1.16[0.51; 2.60]4113133%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate De Santis, 2009De Santis, 2009 2.48[1.15; 5.34]3320635%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Bar-Oz, 2000Bar-Oz, 2000 3.25[1.43; 7.40]3319932%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 39% 2.11[1.16; 3.82]1075360.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.11[1.16; 3.82]10753639%NAMolgaard-Nielsen (Controls unexposed, NOS), 2016 De Santis, 2009 Bar-Oz, 2000 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.11[1.16; 3.82]10753639%NAMolgaard-Nielsen (Controls unexposed, NOS), 2016 De Santis, 2009 Bar-Oz, 2000 3 Tags Adjustment   - No  - No 2.81[1.60; 4.93]664050%NADe Santis, 2009 Bar-Oz, 2000 2   - Yes  - Yes 1.16[0.51; 2.62]41131 -NAMolgaard-Nielsen (Controls unexposed, NOS), 2016 1 MatchedMatched 2.11[1.16; 3.82]10753639%NAMolgaard-Nielsen (Controls unexposed, NOS), 2016 De Santis, 2009 Bar-Oz, 2000 3 All studiesAll studies 2.11[1.16; 3.82]10753639%NAMolgaard-Nielsen (Controls unexposed, NOS), 2016 De Santis, 2009 Bar-Oz, 2000 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17550

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.11[1.16; 3.82]10753639%NAMolgaard-Nielsen (Controls unexposed, NOS), 2016 De Santis, 2009 Bar-Oz, 2000 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.13[0.52; 2.48]150131 -NAMolgaard-Nielsen (Controls exposed to pivmecillinam), 2016 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Liu (Spontaneous abortion (Cohort studies))Liu (Spontaneous abortion (Cohort studies)) 1.44[0.38; 5.43]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg 2.11[1.16; 3.82]39%536----Molgaard-Nielsen (Controls unexposed, NOS), 2016 De Santis, 2009 Bar-Oz, 2000 30.510.01.0