metaPreg - Clotrimazole during pregnancy

Clotrimazole updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.04 [0.93, 1.17]	0%	3 studies	30,990	3,830	not evaluable	ROB	-
Cleft lip with or without cleft palate	0.86 [0.48, 1.54]	0%	3 studies	2,288	2,516	not evaluable	ROB	-
Congenital heart defects	0.94 [0.73, 1.20]	0%	3 studies	8,965	2,542	not evaluable	ROB	-
Gastroschisis	1.31 [0.21, 8.40]	0%	2 studies	658	508	not evaluable	ROB	-
Hypospadias	1.04 [0.66, 1.64]	0%	2 studies	3,171	541	not evaluable	ROB	-
Major congenital malformations	1.03 [0.88, 1.20]	29%	2 studies	24,426	2,744	not evaluable	ROB	-
Neural Tube Defects	0.92 [0.48, 1.78]	0%	2 studies	1,952	254	not evaluable	ROB	-
Ano-rectal atresia and stenosis	3.27 [0.40, 26.73]	-	1 study	209	8	not evaluable	ROB	-
Bilateral renal agenesis including Potter syndrome	0.61 [0.04, 9.82]	-	1 study	54	498	not evaluable	ROB	-
Cleft palate	0.52 [0.09, 2.93]	-	1 study	506	500	not evaluable	ROB	-
Club foot / Talipes equinovarus	1.14 [0.68, 1.92]	-	1 study	2,009	530	not evaluable	ROB	-
Craniosynostosis	3.06 [0.63, 14.78]	-	1 study	447	9	not evaluable	ROB	-
Diaphragmatic hernia	1.16 [0.07, 20.32]	-	1 study	275	7	not evaluable	ROB	-
Digestive system anomalies	1.30 [0.64, 2.63]	-	1 study	307	1,993	not evaluable	ROB	-
Ear malformations	1.12 [0.16, 7.98]	-	1 study	282	500	not evaluable	ROB	-
Genital anomalies	0.98 [0.12, 7.98]	-	1 study	84	500	not evaluable	ROB	-
Hydrocephaly	1.67 [0.27, 10.30]	-	1 study	284	503	not evaluable	ROB	-
Limb defects	1.04 [0.73, 1.49]	-	1 study	1,458	1,993	not evaluable	ROB	-
Limb reduction defects (LRD)	1.03 [0.36, 2.97]	-	1 study	448	507	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	0.30 [0.11, 0.85]	-	1 study	109	45	not evaluable	ROB	6.12 [.; 1.64]
Nervous system anomalies	1.11 [0.69, 1.78]	-	1 study	807	1,993	not evaluable	ROB	-
Oesophageal atresia with or without tracheo-oesophageal fistula	5.60 [0.55, 56.88]	-	1 study	221	4	not evaluable	ROB	-
Polydactyly	1.29 [0.63, 2.64]	-	1 study	1,372	518	not evaluable	ROB	-
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Leukemia	0.94 [0.39, 2.25]	-	1 study	243	24	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.05 [0.89, 1.24]	-	1 study	6,461	2,712	not evaluable	ROB	-
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