Clotrimazole updated on 01-29-2025

Limb defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17541
R73853		 Rotem, 2018 Musculoskeletal system 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Route of exposure Azoles: Vaginal 1.04 [0.73;1.49] 31/1,993   1,427/95,781 1,458 1,993
ref
Total 1 studies 1.04 [0.73;1.49] 1,458 1,993
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rotem, 2018Rotem, 2018 1.04[0.73; 1.49]1,4581,9930%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.04[0.73; 1.49]1,4581,993 -NARotem, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.04[0.73; 1.49]1,4581,993 -NARotem, 2018 1 Tags Adjustment   - Yes  - Yes 1.04[0.73; 1.49]1,4581,993 -NARotem, 2018 1 Route of exposure Azoles   - Vaginal  - Vaginal 1.04[0.73; 1.49]1,4581,993 -NARotem, 2018 1 All studiesAll studies 1.04[0.73; 1.49]1,4581,993 -NARotem, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.04[0.73; 1.49]1,4581,993 -NARotem, 2018 10.510.01.0