Itraconazole updated on 01-29-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.20 [0.83, 1.72]0%4 studies25,2311,094not evaluable ROB-
Major congenital malformations1.20 [0.83, 1.72]0%4 studies25,2311,094not evaluable ROB-
Congenital heart defects3.73 [0.43, 32.30]-1 study688not evaluable ROB-
Limb defects2.33 [0.29, 18.83]-1 study988not evaluable ROB-
Oro-facial clefts6.20 [0.25, 153.31]-1 study188not evaluable ROB-
Polydactyly1.69 [0.09, 30.75]-1 study588not evaluable ROB-
Spina bifida3.72 [0.18, 78.03]-1 study288not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.44 [0.48, 4.35]67%2 studies42281not evaluable ROB-
Low birth weight (< 2500g)0.28 [0.03, 2.56]-1 study5152not evaluable ROB-
Macrosomia (> 4000g)1.69 [0.63, 4.55]-1 study17152not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean--0 study-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neonatal disorders (as a whole)0.80 [0.57, 1.11]0%2 studies66319not evaluable ROB-
Low Apgar score (< 7) (at 1 min)--0 study-
Low Apgar score (< 7) (at 5 min)--0 study-
Very low Apgar score (< 5) (at 1 min)--0 study-
Very low Apgar score (< 5) (at 5 min)--0 study-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)2.11 [1.16, 3.82]39%3 studies107536not evaluable ROB3.64 [1.60; .]
Elective/induced termination of pregnancy5.29 [1.07, 26.22]56%2 studies42405not evaluable ROB10.06 [1.34; .]
Late intrauterine deaths (> 22 weeks)1.78 [0.37, 8.53]0%2 studies6405not evaluable ROB-
Intrauterine deaths (as a whole or unspecified)1.75 [1.47, 2.09]-1 study54199not evaluable ROB2.90 [2.30; .]

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