Itraconazole updated on 01-29-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17548
R73903		 De Santis, 2009 Low birth weight (<2500 g) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.28 [0.03;2.56] C 1/152   4/175 5 152
ref
Total 1 studies 0.28 [0.03;2.56] 5 152
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF De Santis, 2009De Santis, 2009 0.28[0.03; 2.56]51520%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.28[0.03; 2.56]5152 -NADe Santis, 2009 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.28[0.03; 2.56]5152 -NADe Santis, 2009 1 Tags Adjustment   - No  - No 0.28[0.03; 2.56]5152 -NADe Santis, 2009 1 MatchedMatched 0.28[0.03; 2.56]5152 -NADe Santis, 2009 1 All studiesAll studies 0.28[0.03; 2.56]5152 -NADe Santis, 2009 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.28[0.03; 2.56]5152 -NADe Santis, 2009 10.510.01.0