metaPreg - Primidone (All indications) during pregnancy

Primidone (All indications)

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	2.74 [1.43, 5.24]	0%	10 studies	49,650	161	low	ROB	4.92 [2.22; .]
Major congenital malformations	2.45 [1.08, 5.52]	9%	8 studies	49,633	122	not evaluable	ROB	4.33 [1.38; .]
Cleft lip with or without cleft palate	31.57 [0.54, 1833.75]	-	1 study		4	not evaluable	ROB	-
Minor congenital malformations	3.46 [0.38, 31.70]	0%	2 studies	12	33	not evaluable	ROB	-
Neural Tube Defects	1.01 [0.06, 17.08]	0%	2 studies	1	41	not evaluable	ROB	-
Club foot / Talipes equinovarus	1.91 [0.03, 109.96]	-	1 study	1	7	not evaluable	ROB	-
Congenital heart defects	0.16 [0.01, 3.56]	-	1 study	5	6	not evaluable	ROB	-
Eye defects	1.62 [0.06, 44.25]	-	1 study	6	2	not evaluable	ROB	-
Hypospadias	0.29 [0.01, 7.14]	-	1 study	3	6	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	2.33 [0.55, 9.99]	-	1 study	10	34	not evaluable	ROB	-
Polydactyly	0.49 [0.02, 13.92]	-	1 study	2	6	not evaluable	ROB	-
Spina bifida	0.71 [0.01, 49.71]	-	1 study	1	3	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Small for gestational age (weight)	4.47 [0.14, 140.06]	56%	2 studies	599	21	not evaluable	ROB	-
Preterm (< 37 weeks)	6.23 [0.60, 64.99]	70%	2 studies	391	34	not evaluable	ROB	-
Low birth weight (< 2500g)	1.06 [0.14, 7.97]	-	1 study	250	20	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation	63.00 [0.51, 7760.63]	-	1 study		1	not evaluable	ROB	-
Feeding difficulty	20.33 [0.29, 1423.95]	-	1 study	1	1	not evaluable	ROB	-
Neonatal intracranial hemorrhage	11.80 [0.19, 731.60]	-	1 study	2	1	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Perinatal death	0.71 [0.01, 37.03]	-	1 study		35	not evaluable	ROB	-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Cognitive developmental disorders/delay (> 6 years old)	0.45 [0.02, 12.49]	-	1 study	1	9	not evaluable	ROB	-
Neuro-developmental disorders (as a whole)	2.15 [0.15, 30.90]	0%	2 studies	4	4	not evaluable	ROB	-
Severe cognitive developmental delay (Mental retardation) (> 6 years old)	0.45 [0.02, 12.49]	-	1 study	1	9	not evaluable	ROB	-
Psychomotor developmental disorders/delay	1.67 [0.26, 10.64]	-	1 study	6	11	not evaluable	ROB	-
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