Primidone (All indications)

Preterm (< 37 weeks)

id	Study   Auto Kilic (Primidone) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014Kilic (Primidone) (Controls unexposed NOS) (Mixed indications), 2014Kilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014Koch (Primidone), 1996	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9481 R33342	Kilic (Primidone) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014	Preterm (< 37 weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	1.69 [0.49;5.90] C excluded (control group)	3/20   83/880	86	20		ref
S9482 R33345	Kilic (Primidone) (Controls unexposed NOS) (Mixed indications), 2014	Preterm (< 37 weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: No	3.34 [0.98;11.40] C excluded (control group)	3/20   33,974/676,834	33,977	20		ref
S9483 R33348	Kilic (Primidone) (Controls unexposed, sick) (Mixed indications), 2014	Preterm (< 37 weeks)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No Controls: epilepsy indication	2.26 [0.66;7.76] C	3/20   383/5,296	386	20		ref
S9478 R33336	Koch (Primidone), 1996	Prematurity (< 37 weeks)	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: No Matched	25.60 [2.59;252.91] C	4/14   1/65	5	14		ref
					Total	2 studies	6.23 [0.60;64.99]		391	34
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 9481, 9482