Primidone (All indications)

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9457
R33271		 Dean (Primidone), 2002 Developmental delay at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.48 [0.09;70.62] C 0/2   4/38 4 2
ref
S9460
R33289		 Katz (Primidone), 2001 Developmental delay (Based on the DSM-IV-TR criteria) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No 1.67 [0.02;137.36] C 0/2   0/3 0 2
ref
Total 2 studies 2.15 [0.15;30.90] 4 4
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dean (Primidone), 2002Dean, 2002 1 2.48[0.09; 70.62]4263%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Katz (Primidone), 2001Katz, 2001 2 1.67[0.02; 137.36]0237%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.15[0.15; 30.90]440.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone; 2: Primidone;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.15[0.15; 30.90]440%NADean (Primidone), 2002 Katz (Primidone), 2001 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.48[0.09; 70.62]42 -NADean (Primidone), 2002 1 exposed to other treatment, sickexposed to other treatment, sick 1.67[0.02; 137.36]-2 -NAKatz (Primidone), 2001 1 Tags Adjustment   - No  - No 2.15[0.15; 30.90]440%NADean (Primidone), 2002 Katz (Primidone), 2001 2 All studiesAll studies 2.15[0.15; 30.90]440%NADean (Primidone), 2002 Katz (Primidone), 2001 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.48[0.09; 70.62]42 -NADean (Primidone), 2002 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.67[0.02; 137.36]-2 -NAKatz (Primidone), 2001 10.510.01.0