Primidone (All indications)

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9457
R33270		 Dean (Primidone), 2002 Minor congenital malformations at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.97 [0.07;54.80] C 0/2   5/38 5 2
ref
S9463
R33306		 Battino (Primidone), 1992 Minor anomalies 1st trimester prospective cohort unexposed, sick Adjustment: No 5.43 [0.28;105.58] C 7/31   0/9 7 31
ref
Total 2 studies 3.46 [0.38;31.70] 12 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dean (Primidone), 2002Dean, 2002 1 1.97[0.07; 54.80]5244%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Battino (Primidone), 1992Battino, 1992 2 5.43[0.28; 105.58]73156%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 3.46[0.38; 31.70]12330.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone; 2: Primidone;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.46[0.38; 31.70]12330%NADean (Primidone), 2002 Battino (Primidone), 1992 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.46[0.38; 31.70]12330%NADean (Primidone), 2002 Battino (Primidone), 1992 2 Tags Adjustment   - No  - No 3.46[0.38; 31.70]12330%NADean (Primidone), 2002 Battino (Primidone), 1992 2 All studiesAll studies 3.46[0.38; 31.70]12330%NADean (Primidone), 2002 Battino (Primidone), 1992 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.46[0.38; 31.70]12330%NADean (Primidone), 2002 Battino (Primidone), 1992 20.510.01.0