Primidone (All indications)

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9461
R33290		 Bànhidy (Primidone), 2011 Neural tube defects throughout pregnancy case control unexposed, sick Adjustment: No Matched 1.46 [0.03;83.47] C 0/6   1/11 1 6
ref
S9464
R33310		 Canger (Primidone), 1999 Neural tube defects 1st trimester prospective cohort unexposed, sick Adjustment: No 0.71 [0.01;37.03] C 0/35   0/25 0 35
ref
Total 2 studies 1.01 [0.06;17.08] 1 41
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Primidone), 2011Bànhidy, 2011 1 1.46[0.03; 83.47]1649%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Canger (Primidone), 1999Canger, 1999 2 0.71[0.01; 37.03]03551%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.01[0.06; 17.08]1410.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Primidone; 2: Primidone;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.71[0.01; 37.03]-35 -NACanger (Primidone), 1999 1 case control studiescase control studies 1.46[0.03; 83.47]16 -NABànhidy (Primidone), 2011 1 Type of controls unexposed, sickunexposed, sick 1.01[0.06; 17.08]1410%NABànhidy (Primidone), 2011 Canger (Primidone), 1999 2 Tags Adjustment   - No  - No 1.01[0.06; 17.08]1410%NABànhidy (Primidone), 2011 Canger (Primidone), 1999 2 MatchedMatched 1.46[0.03; 83.47]16 -NABànhidy (Primidone), 2011 1 All studiesAll studies 1.01[0.06; 17.08]1410%NABànhidy (Primidone), 2011 Canger (Primidone), 1999 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.01[0.06; 17.08]1410%NABànhidy (Primidone), 2011 Canger (Primidone), 1999 20.510.01.0