metaPreg - Chlordiazepoxide during pregnancy

Chlordiazepoxide updated on 02-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.18 [0.82, 1.70]	48%	5 studies	161,237	738	not evaluable	ROB	-
Major congenital malformations	1.47 [1.14, 1.89]	0%	4 studies	158,496	476	not evaluable	ROB	2.30 [1.54; .]
Congenital heart defects	1.75 [0.91, 3.39]	41%	3 studies	83,986	389	not evaluable	ROB	-
Cleft lip with or without cleft palate	1.12 [0.33, 3.81]	0%	2 studies	630	6	not evaluable	ROB	-
Limb reduction defects (LRD)	-	-	0 study					-
10 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
2 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks) / Stillbirths	1.12 [0.65, 1.90]	0%	2 studies	26,794	1,129	not evaluable	ROB	-
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.42 [0.38, 5.36]	29%	2 studies	27,200	193	not evaluable	ROB	-