Lisinopril (versus unexposed)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Chintamaneni, 2018	retrospective cohort (claims database)	Pregnant women exposed to angiotensin-converting enzyme inhibitors (Ace-i) during pregnancy were identified using pharmacy dispensing records.	Maternal co-morbidities and fetal congenital cardiac anomalies were identified by searching electronic medical records using ICD9-CM codes.	Malformations: adjusted for maternal age, ethnicity, and maternal comorbidities (certainly hypertension, heart failure, diabetes, and chronic renal insufficiency). No adjustment for other outcomes. Singletons only.