metaPreg - Alprazolam during pregnancy

Alprazolam updated on 02-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.50 [0.96, 2.35]	85%	3 studies	206,551	1,999	not evaluable	ROB	-
Congenital heart defects	1.31 [0.74, 2.32]	82%	3 studies	95,847	1,987	not evaluable	ROB	-
Major congenital malformations	1.53 [0.93, 2.51]	92%	2 studies	206,531	1,917	not evaluable	ROB	-
Hypospadias	0.30 [0.10, 0.90]	-	1 study	2,540		not evaluable	ROB	6.12 [.; 1.46]
Oesophageal atresia with or without tracheo-oesophageal fistula	2.70 [1.22, 5.99]	-	1 study	753	46	not evaluable	ROB	4.84 [1.73; .]
Anophthalmos/micropthalmos	4.00 [1.21, 13.22]	-	1 study	230	41	not evaluable	ROB	7.46 [1.72; .]
Atresia or stenosis of other parts of small intestine	-	-	0 study					-
Bilateral renal agenesis including Potter syndrome	-	-	0 study					-
Club foot / Talipes equinovarus	-	-	0 study					-
Ear malformations	-	-	0 study					-
Genital anomalies	-	-	0 study					-
Limb reduction defects (LRD)	-	-	0 study					-
Microcephaly / Small head circumference for gestational age	-	-	0 study					-
Oro-facial clefts	-	-	0 study					-
Polydactyly	-	-	0 study					-
23 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Small for gestational age (weight)	2.05 [0.57, 7.42]	83%	2 studies	277,483	14,187	not evaluable	ROB	-
Low birth weight (< 2500g)	2.11 [0.72, 6.12]	48%	2 studies	32	128	not evaluable	ROB	-
Preterm (< 37 weeks)	1.40 [0.81, 2.41]	49%	2 studies	276,199	14,220	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low Apgar score (< 7) (at 1 min)	-	-	0 study					-
Low Apgar score (< 7) (at 5 min)	-	-	0 study					-
1 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.48 [1.12, 1.97]	65%	4 studies	45,271	455	not evaluable	ROB	2.33 [1.48; .]
Late intrauterine deaths (> 22 weeks) / Stillbirths	0.99 [0.84, 1.16]	0%	2 studies	32,534	14,395	not evaluable	ROB	-
1 non statistically significant endpoints reported in only one study