metaPreg - Ketoconazole (all routes except local only) during pregnancy

Ketoconazole (all routes except local only) updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.25 [0.49, 3.18]	0%	2 studies	48,004	83	not evaluable	ROB	-
Congenital heart defects	3.11 [0.81, 11.97]	0%	2 studies	7,528	11	not evaluable	ROB	-
Major congenital malformations	1.25 [0.49, 3.18]	0%	2 studies	48,004	83	not evaluable	ROB	-
Ano-rectal atresia and stenosis	7.63 [0.31, 187.87]	-	1 study	209	1	not evaluable	ROB	-
Cleft lip with or without cleft palate	1.47 [0.06, 36.00]	-	1 study	1,086	1	not evaluable	ROB	-
Craniosynostosis	3.56 [0.14, 87.59]	-	1 study	447	1	not evaluable	ROB	-
Diaphragmatic hernia	5.80 [0.24, 142.60]	-	1 study	275	1	not evaluable	ROB	-
Gastroschisis	3.50 [0.14, 86.05]	-	1 study	455	1	not evaluable	ROB	-
Hypospadias	6.16 [0.38, 98.57]	-	1 study	776	2	not evaluable	ROB	-
Neural Tube Defects	6.37 [0.40, 101.99]	-	1 study	750	2	not evaluable	ROB	-
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