Ketoconazole (all routes except local only) updated on 01-29-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10627
R39293		 Carter, 2008 Cardiovascular defects 1st trimester case control unexposed (general population or NOS) Adjustment: No 3.13 [0.28;34.57] C 2/3   3,047/7,820 3,049 3
ref
S17564
R74040		 Kazy, 2005 Cardiovascular congenital anomalies 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 3.10 [0.60;15.60] 2/8   4,477/42,622 4,479 8
ref
Total 2 studies 3.11 [0.81;11.97] 7,528 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Carter, 2008Carter, 2008 3.13[0.28; 34.57]3,049332%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate Kazy, 2005Kazy, 2005 3.10[0.60; 15.60]4,479868%ROB confusion: unclearROB selection: criticalROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 3.11[0.81; 11.97]7,528110.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.11[0.81; 11.97]7,528110%NACarter, 2008 Kazy, 2005 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.11[0.81; 11.97]7,528110%NACarter, 2008 Kazy, 2005 2 Tags Adjustment   - No  - No 3.13[0.28; 34.57]3,0493 -NACarter, 2008 1   - Yes  - Yes 3.10[0.61; 15.81]4,4798 -NAKazy, 2005 1 All studiesAll studies 3.11[0.81; 11.97]7,528110%NACarter, 2008 Kazy, 2005 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.11[0.81; 11.97]7,528110%NACarter, 2008 Kazy, 2005 20.510.01.0