Interferon beta 1a (IFN-beta1a) updated on 07-06-2020

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)0.55 [0.10, 2.97]-1 study740not evaluable ROB-
Major congenital malformations0.19 [0.01, 3.85]-1 study340not evaluable ROB-
Congenital cataract--0 study-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.16 [0.45, 2.99]63%3 studies249292not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preeclampsia1.10 [0.11, 10.95]-1 study429not evaluable ROB-
Gestational diabetes0.44 [0.02, 11.17]-1 study129not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Jaundice / Icterus0.81 [0.16, 4.02]-1 study1029not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Child/Infant infections (> 1 year)3.75 [1.00, 14.02]-1 study1029not evaluable ROB6.96 [1.06; .]
Child/Infant weight abnormalities (> 1 year)3.36 [0.20, 55.42]-1 study229not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)0.73 [0.41, 1.31]0%2 studies71292not evaluable ROB-
Elective/induced termination of pregnancy1.62 [0.83, 3.13]-1 study41250not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Psychomotor developmental disorders/delay10.31 [0.41, 260.28]-1 study129not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis10.31 [0.41, 260.28]-1 study129not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis/Risk10.31 [0.41, 260.28]-1 study129not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis0.65 [0.03, 13.92]-1 study229not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk0.65 [0.03, 13.92]-1 study229not evaluable ROB-
Cognitive developmental disorders/delay (> 6 years old)1.66 [0.15, 19.00]-1 study329not evaluable ROB-
Language disorders/delay0.44 [0.02, 11.17]-1 study129not evaluable ROB-
Learning disorders 1.09 [0.04, 27.59]-1 study129not evaluable ROB-

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