Interferon beta 1a (IFN-beta1a)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3705
R7906		 Nguyen (control exposed to Glatiramer), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.62 [0.26;1.49] C
excluded (control group) 		13/250   9/110 22 250
ref
S3707
R7912		 Nguyen (control unexposed, sick), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.78 [0.42;1.47] C 13/250   50/763 63 250
ref
S3698
R7878		 Weber-Schoendorfer (control exposed to Glatiramer), 2009 Miscarriage at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.25 [0.11;14.51] C
excluded (control group) 		2/42   1/26 3 42
ref
S3700
R7886		 Weber-Schoendorfer (control unexposed, disease free), 2009 Miscarriage at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 0.50 [0.12;2.09] C
excluded (control group) 		2/42   138/1,515 140 42
ref
S3702
R7894		 Weber-Schoendorfer (control unexposed, sick), 2009 Miscarriage at least 1st trimester prospective cohort unexposed, sick Adjustment: No 0.46 [0.09;2.39] C 2/42   6/61 8 42
ref
Total 2 studies 0.73 [0.41;1.31] 71 292
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 0.78[0.42; 1.47]6325087%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Weber-Schoendorfer (control unexposed, sick), 2009Weber-Schoendorfer, 2009 2 0.46[0.09; 2.39]84213%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.73[0.41; 1.31]712920.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.73[0.41; 1.31]712920%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.73[0.41; 1.31]712920%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 Tags Adjustment   - No  - No 0.73[0.41; 1.31]712920%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 All studiesAll studies 0.73[0.41; 1.31]712920%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3698, 3700, 3705

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.50[0.12; 2.09]14042 -NAWeber-Schoendorfer (control unexposed, disease free), 2009 1 unexposed, sick controlsunexposed, sick controls 0.73[0.41; 1.31]712920%NANguyen (control unexposed, sick), 2019 Weber-Schoendorfer (control unexposed, sick), 2009 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.67[0.29; 1.53]252920%NANguyen (control exposed to Glatiramer), 2019 Weber-Schoendorfer (control exposed to Glatiramer), 2009 20.510.01.0