Interferon beta 1a (IFN-beta1a) updated on 07-06-2020

ASD (Autism spectrum disorder): Diagnosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3709
R7924		 Fragoso a (control exposed to Glatiramer), 2013 Asperger syndrome - - At mean age of 6.6 ± 6.9 years (range 1–39 years) during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 4.20 [0.16;107.01] C
excluded (control group) 		1/29   0/39 1 29
ref
S3711
R7966		 Fragoso a (control unexposed, sick), 2013 Asperger syndrome - At mean age of 6.6 ± 6.9 years (range 1–39 years) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 10.31 [0.41;260.28] C 1/29   0/95 1 29
ref
Total 1 studies 10.31 [0.41;260.28] 1 29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso a (control unexposed, sick), 2013Fragoso a, 2013 1 10.31[0.41; 260.28]1290%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 10.31[0.41; 260.28]129 -NAFragoso a (control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 10.31[0.41; 260.28]129 -NAFragoso a (control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 10.31[0.41; 260.28]129 -NAFragoso a (control unexposed, sick), 2013 1 All studiesAll studies 10.31[0.41; 260.28]129 -NAFragoso a (control unexposed, sick), 2013 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3709

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale10.31[0.41; 260.28]129 -NAFragoso a (control unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.20[0.16; 107.01]129 -NAFragoso a (control exposed to Glatiramer), 2013 10.510.01.0