Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Study Reference
Abd Rahman, 2020

Abd Rahman New Benefits of Hydroxychloroquine in Pregnant Women with Systemic Lupus Erythematosus: A Retrospective Study in a Tertiary Centre. Rev Bras Ginecol Obstet 2020; 42:705-711

Al Arfaj, 2010

Al Arfaj Pregnancy outcome in 396 pregnancies in patients with SLE in Saudi Arabia. Lupus 2010; 19:1665-73

Andersson (Controls exposed to corticosteroides), 2021

Andersson Fetal safety of chloroquine and hydroxychloroquine use during pregnancy: a nationwide cohort study. Rheumatology (Oxford) 2021; 60:2317-2326

Andersson (Controls unexposed, NOS), 2021

Andersson Fetal safety of chloroquine and hydroxychloroquine use during pregnancy: a nationwide cohort study. Rheumatology (Oxford) 2021; 60:2317-2326

Andreoli, 2022

Andreoli Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals. Clin Rev Allergy Immunol 2022; 62:346-353

Baalbaki, 2020

Baalbaki Systemic Lupus Erythematosus: Perinatal Outcomes in Patients Treated With and Without Hydroxychloroquine. Ochsner J 2020; 20:362-367

Baalbaki, S. Systemic lupus erythematosus: Outcomes in women treated with and without hydroxychloroquine Am. J. Obstet. Gynecol. 2015; 212:S273-.

Bérard, 2021

Bérard Available medications used as potential therapeutics for COVID-19: What are the known safety profiles in pregnancy. PLoS One 2021; 16:e0251746

Braga, 2021

Braga Systemic lupus erythematosus and pregnancy: A retrospective single-center study of 215 pregnancies from Portugal. Lupus 2021; 30:2165-2175

Buchanan, 1996

Buchanan Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases. Ann. Rheum. Dis. 1996; 55:486-8

Khamashta The use of hydroxychloroquine in lupus pregnancy: the British experience. Lupus 1996; 5 Suppl 1:S65-6

Canti, 2021

Canti Low incidence of intrauterine growth restriction in pregnant patients with systemic lupus erythematosus taking hydroxychloroquine. Immunol Med 2021; 44:204-210

Chakravarty, 2005

Chakravarty Factors that predict prematurity and preeclampsia in pregnancies that are complicated by systemic lupus erythematosus. Am. J. Obstet. Gynecol. 2005; 192:1897-904

Chambers (Controls unexposed, disease free), 2022

Chambers Birth Outcomes in Women Who Have Taken Hydroxycholoroquine During Pregnancy: A Prospective Cohort Study. Arthritis Rheumatol 2022; 74:711-724

Chambers (Controls unexposed, sick), 2022

Chambers Birth Outcomes in Women Who Have Taken Hydroxycholoroquine During Pregnancy: A Prospective Cohort Study. Arthritis Rheumatol 2022; 74:711-724

Cimaz, 2007

Cimaz Response to tetanus vaccination in infants exposed in utero to immunosuppressants for maternal autoimmune disorders. Lupus 2007; 16:129-32

Clowse, 2006

Clowse Hydroxychloroquine in lupus pregnancy. Arthritis Rheum. 2006; 54:3640-7

Colvin, 2010

Colvin Linking a pharmaceutical claims database with a birth defects registry to investigate birth defect rates of suspected teratogens. Pharmacoepidemiol Drug Saf 2010; 19:1137-50

Cooper (controls exposed to TNF-I), 2014

Cooper Brief report: Risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy. 2014; 66:444-50

Cooper (controls unexposed, sick), 2014

Cooper Brief report: Risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy. 2014; 66:444-50

Costedoat-Chalumeau, 2003

Costedoat-Chalumeau Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group. Arthritis Rheum. 2003; 48:3207-11

Diav-Citrin, 2013

Diav-Citrin Pregnancy outcome following in utero exposure to hydroxychloroquine: a prospective comparative observational study. Reprod. Toxicol. 2013; 39:58-62

Do, 2020

Do Does Hydroxychloroquine Protect against Preeclampsia and Preterm Delivery in Systemic Lupus Erythematosus Pregnancies? Am J Perinatol 2020; :

Frassi, 2004

Frassi Hydroxychloroquine in pregnant patients with rheumatic disease: a case control observation of 76 treated pregnancies. Lupus. 2004;13:755.

Gernaat (Controls unexposed, disease free), 2022

Gernaat Gestational Diabetes Mellitus Risk in Pregnant Women With Systemic Lupus Erythematosus. J Rheumatol 2022; 49:465-469

Gernaat (Controls unexposed, sick), 2022

Gernaat Gestational Diabetes Mellitus Risk in Pregnant Women With Systemic Lupus Erythematosus. J Rheumatol 2022; 49:465-469

Haase, 2020

Haase, I. Safety and beneficial effects of hydroxychloroquine on pregnancy outcomes in women with systemic lupus erythematosus Ann. Rheum. Dis. 2020; 79:1486-.

Haase, 2021

Haase, I. Sle pregnancies at high risk for preeclampsia benefit most from combination of low dose aspirin and hydroxychloroquine Ann. Rheum. Dis. 2021; 80:1195-.

He, 2022

He Pregnancy outcomes in Takayasu arteritis patients. Semin Arthritis Rheum 2022; 55:152016

Howley - BDS study, 2021

Howley Maternal exposure to hydroxychloroquine and birth defects. Birth Defects Res 2021; 113:1245-1256

Howley - NBDPS study, 2021

Howley Maternal exposure to hydroxychloroquine and birth defects. Birth Defects Res 2021; 113:1245-1256

Howren, 2020

Howren Perinatal exposure to conventional synthetic disease-modifying anti-rheumatic drugs in women with rheumatic disease and neonatal outcomes: a population-based study. Clin. Exp. Rheumatol. 2020; :

Huybrechts (Controls unexposed, NOS), 2021

Huybrechts Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol 2021; 224:290.e1-290.e22

Huybrechts (Controls unexposed, sick), 2021

Huybrechts Hydroxychloroquine early in pregnancy and risk of birth defects. Am J Obstet Gynecol 2021; 224:290.e1-290.e22

Kiatkongchuchai, 2020

Kiatkongchuchai, P. Factors associated with preeclampsia in SLE patients during pregnancy Int. J. Rheum. Dis. 2020; 23:300-.

Kroese, 2017

Kroese Hydroxychloroquine Use in Lupus Patients during Pregnancy Is Associated with Longer Pregnancy Duration in Preterm Births. J Immunol Res 2017; 2017:2810202

Langen, 2014

Langen High rate of preterm birth in pregnancies complicated by rheumatoid arthritis. Am J Perinatol 2014; 31:9-14

Leroux, 2015

Leroux Impact of hydroxychloroquine on preterm delivery and intrauterine growth restriction in pregnant women with systemic lupus erythematosus: a descriptive cohort study. Lupus 2015; 24:1384-91

Levy, 2001

Levy Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind and placebo-controlled study. Lupus 2001; 10:401-4

Liu, 2021

Liu Effect of hydroxychloroquine on preeclampsia in lupus pregnancies: a propensity score-matched analysis and meta-analysis. Arch Gynecol Obstet 2021; 303:435-441

Louthrenoo, 2021

Louthrenoo Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus: A STROBE-compliant study. Medicine (Baltimore) 2021; 100:e24553

Mollerach, 2019

Mollerach Causes of fetal third-degree atrioventricular block and use of hydroxychloroquine in pregnant women with Ro/La antibodies. Clin. Rheumatol. 2019; 38:2211-2217

Moroni, 2016

Moroni Fetal outcome and recommendations of pregnancies in lupus nephritis in the 21st century. A prospective multicenter study. J. Autoimmun. 2016; 74:6-12

Placais, 2019

Placais Obstetrical morbidity related to anti-SSA antibodies: Data from a French monocentric retrospective study. Joint Bone Spine 2019; 86:523-524

Poh, 2020

Poh Maternal and Fetal Outcomes in Systemic Lupus Erythematosus Pregnancies. Ann Acad Med Singap 2020; 49:963-970

Reynolds, 2022

Reynolds Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine. Rheumatology (Oxford) 2022; :

Seo, 2019

Seo Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia. Lupus 2019; 28:722-730

Tang, 2022

Tang The efficacy and safety of hydroxychloroquine in pregnant patients with IgA nephropathy: A retrospective cohort study. Nephrology (Carlton) 2022; 27:155-161

Tincani, 2005

Tincani Pregnancy and autoimmunity: maternal treatment and maternal disease influence on pregnancy outcome. Autoimmun Rev 2005; 4:423-8

Viktil (Controls exposed to other treatments), 2012

Viktil Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers. Scand J Rheumatol 2012; 41:196-201

Viktil (Controls unexposed, NOS), 2012

Viktil Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers. Scand J Rheumatol 2012; 41:196-201

Vroom (controls exposed to sulfasalazine), 2009

Vroom Drug use in pregnancy: exploring the field of Disease Modifying Antirheumatic Drugs in pregnancy Thesis, DMARDs in pregnancy: birth outcomes after prescribing DMARDs using the GPRD, 2009, 207p.

Vroom (controls unexposed, disease free), 2009

Vroom Drug use in pregnancy: exploring the field of Disease Modifying Antirheumatic Drugs in pregnancy Thesis, DMARDs in pregnancy: birth outcomes after prescribing DMARDs using the GPRD, 2009, 207p.

Zhang, 2022

Zhang Clinical study of factors associated with pregnancy outcomes in pregnant women with systemic lupus erythematosus in the southern China. Arch Rheumatol 2022; 37:59-66