Valsartan (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Hoeltzenbein, 2018	Germany 2000 - 2014	Pregnancies ascertained through risk consultation by the German Embryotox pharmacovigilance institute.	Pregnancies in hypertensive women with Valsartan exposure in the first trimester of pregnancy.	unexposed, disease free Pregnant women randomly selected among those ascertained through risk consultation without a diagnosis of hypertension or treatment of hypertension during pregnancy.	41 / 642	The most frequently used ARBs were candesartan (n = 76, median daily dose 16 mg) and valsartan (n = 41, median daily dose 80 mg). Treatment indication was hypertension in 97% of patients. ARBs were discontinued at the median GW 6.29 (IQR 5.0–8.14).

Study	Country Study period	Case	Control	Sample size	Rmk