Valsartan (versus unexposed)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Hoeltzenbein, 2018	prospective cohort	Prospective observational cohort study, i.e., the outcome of the evaluated pregnancies was not known at the time of case enrollment. => Exposure collected at the time of enrollment when health care professionals and patients called the service.	Outcome of pregnancy is collected via mailed questionnaires about 8 weeks after the estimated date of birth. Additional medical records are requested in cases of anomalies or implausible information	No adjustment for this group of exposure. Matched by year of enrollment. Exclusion of pregnancies exposed to established teratogens.