Nadolol (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Albertini, 2023	Canada 2012 - 2021	Pregnant women with long QT syndrome (LQTS), followed during pregnancy in the tertiary Pregnancy and Heart Disease Program at the University of Toronto.	Babies born to mothers with long QT syndrome who had taken Nadolol during pregnancy.	unexposed, sick Babies born to mothers with long QT syndrome who had not taken beta-blockers during pregnancy.	5 / 7
Delteil, 2024	France 2004 - 2021	Pregnancies with a known outcome between July 2004 and December 2021 in Haute-Garonne, included in the EFEMERIS database.	Pregnancies with at least one dispensed prescription of Nadolol during pregnancy (between last menstrual period and delivery).	unexposed (general population or NOS) Pregnancies without dispensed prescription of beta-blockers and other anti-hypertensive agents during pregnancy.	14 / 172284	When available, data in women with chronic pathology (hypertension or cardiac), treated at least during the 1st trimester were preferred to all indications (including gestational hypertension, ...). Exposure at least T1 considered as chronic indications.

Study	Country Study period	Case	Control	Sample size	Rmk