Miconazole (local route only)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Daniel, 2018	retrospective cohort (claims database)	Medication dispensions during pregnancy were retrieved from the CHS medication database which contains all drug dispensions (prescription or OTC) to all patients insured by CHS in both community and hospital pharmacies.	Data regarding admissions for spontaneous abortions was gathered from the Soroka Medical Center hospitalization database.	Adjusted for mother’s age, hypothyroidism, diabetes mellitus, hypercoagulable state, uterine disorders, the presence of a intrauterine contraceptive device, history of recurrent abortions, IVF on the current pregnancy, inflammatory diseases and ethnicity.
Kazy, 2005	case control	The exposure data were obtained: (i) prospectively through antenatal care logbooks and other medical records; (ii) retrospectively by questionnaires completed by mothers; and (iii) by the help of regional nurses who visited and questioned all nonrespondent case and 200 control mothers.	The Hungarian Congenital Abnormality Registry (HCAR), in which notification by physicians of cases with Congenital anomalies is mandatory. Autopsy was obligatory for all infant deaths during the study period, and pathologists sent a copy of a detailed autopsy report to the Registry.	Controls matched for sex, birth week and district of parents’ residence. Adjusted for maternal age, birth order, marital and employment status, maternal disorders (No details) and other medicine (drug and pregnancy supplement).
Rotem, 2018	retrospective cohort (claims database)	Data for drugs dispensed during pregnancy were provided by the Clalit HMO medication database.	Three databases: the deliveries database provided by the Division of Obstetrics and Gynecology, the SMC paediatric hospitalisation database and SMC pregnancy termination database. All diagnoses were assigned by board-certificated neonatologists and obstetricians.	Adjusted for maternal age, ethnicity (Bedouin versus Jewish), pre-gestational diabetes, smoking, nulliparity, year of delivery/pregnancy termination.

master protocol