Oxazepam (Psy and mixed indications)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Bonnot, 2001	case control	The medical records are checked to obtain data on treatment intake and other exposures or risks.	After having defined a population, often on geographical criteria, these networks set up birth observatories in order to exhaustively identify neonatal malformations in their reference population.	Adjusted for age and parity.
Cornel - The NNL registry, 1996	case control	The registry personnel actively collect information by going through hospital records. Data were supplied by pediatricians, obstetricians, midwives, general practitioners (GP's), clinical geneticists, and several other medical specialists. The data include on maternal drug use during pregnancy.	The registry personnel actively collect information by going through hospital records. Data were supplied by pediatricians, obstetricians, midwives, general practitioners (GP's), clinical geneticists, and several other medical specialists. The data include diagnostic information.	None.
Källén, 2013	population based cohort retrospective	At the midwife interview at the first antenatal care visit, the woman was asked if she had used any drugs since she became pregnant. Or determined by the use of the Swedish Register of Prescribed Drugs (since 2006).	The Swedish Medical Birth Registry contain information based on standardized medical records from the first and further antenatal visit, the delivery and the paediatric examination. Supplemented with data from the Register of Birth Defects and Hospital Discharge Register.	Adjustment was made for year of birth, maternal age (5-year class), parity, smoking in early pregnancy and body mass index.
Sheehy, 2019	nested case control	The Quebec Public Prescription Drug Insurance Plan database (drug name, start date, dose, and duration).	The data sources included the medical service database the Régie de l’assurance maladie du Québec (diagnoses, medical procedures, ...) and the MedEcho database (in-hospital diagnoses and procedures, including gestational age for planned abortions, spontaneous abortions, and deliveries).	Adjusted for (1) maternal sociodemographic variables (2) maternal chronic conditions (hypertension, diabetes, depression/anxiety, alcohol ...), (3) health care resources utilization, (4) pregnancy-associated variables, (5) concomitant exposure to antidepressants and/or antipsychotics. Matched by gestational age and calendar year. Exclusion of women with epilepsy and exposed to known teratogens.

master protocol