metaPreg - Ethosuximide (All indications) during pregnancy

Ethosuximide (All indications)

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	2.81 [1.07, 7.41]	0%	8 studies	49,640	58	not evaluable	ROB	5.07 [1.34; .]
Major congenital malformations	3.05 [1.12, 8.33]	0%	8 studies	49,634	58	not evaluable	ROB	5.55 [1.48; .]
Congenital heart defects	4.26 [0.38, 47.27]	0%	2 studies	9	12	not evaluable	ROB	-
Hypospadias	4.12 [0.37, 45.30]	0%	2 studies	9	12	not evaluable	ROB	-
Neural Tube Defects	18.80 [1.26, 279.89]	0%	2 studies	2	12	not evaluable	ROB	37.09 [1.84; .]
Digestive system anomalies	7.99 [0.39, 163.81]	-	1 study	3	12	not evaluable	ROB	-
Eye defects	5.33 [0.29, 97.49]	-	1 study	7	2	not evaluable	ROB	-
Limb defects	11.21 [0.51, 246.80]	-	1 study	2	12	not evaluable	ROB	-
Minor congenital malformations	2.20 [0.19, 25.52]	-	1 study	6	4	not evaluable	ROB	-
Oro-facial clefts	18.71 [0.72, 484.16]	-	1 study	1	12	not evaluable	ROB	-
Polydactyly	6.33 [0.09, 458.24]	-	1 study	2		not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low birth weight (< 2500g)	20.14 [0.40, 1017.27]	-	1 study	249	1	not evaluable	ROB	-
Preterm (< 37 weeks)	12.81 [0.25, 646.50]	-	1 study	383	1	not evaluable	ROB	-
Small for gestational age (weight)	7.87 [0.16, 397.17]	-	1 study	594	1	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation	-	-	0 study					-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neuro-developmental disorders (as a whole)	8.50 [0.44, 163.89]	-	1 study	5	2	not evaluable	ROB	-
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