metaPreg - Dosulepin / Dothiepin during pregnancy

Dosulepin / Dothiepin updated on 10-20-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.35 [0.55, 3.32]	-	1 study	22,633	83	not evaluable	ROB	-
Congenital heart defects	2.29 [0.72, 7.27]	-	1 study	8,110	83	not evaluable	ROB	-
Major congenital malformations	1.35 [0.55, 3.32]	-	1 study	22,633	83	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Large for gestational age (weight)	0.95 [0.30, 3.00]	-	1 study	9,747	131	not evaluable	ROB	-
Low birth weight (< 2500g)	1.54 [0.93, 2.55]	-	1 study	31,365	131	not evaluable	ROB	-
Preterm (< 37 weeks)	0.97 [0.52, 1.81]	-	1 study	28,554	131	not evaluable	ROB	-
Small for gestational age (weight)	1.89 [0.69, 5.17]	-	1 study	6,990	131	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Assisted deliveries (forceps, vacuum, ...)	0.60 [0.26, 1.37]	-	1 study	46,042	131	not evaluable	ROB	-
Caesarean	0.85 [0.58, 1.24]	-	1 study	111,678	131	not evaluable	ROB	-
Maternal consequences (as a whole)	0.91 [0.63, 1.32]	-	1 study	311,183	131	not evaluable	ROB	-
Postpartum hemorrhage	0.64 [0.20, 2.03]	-	1 study	19,758	131	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low Apgar score (< 7) (at 1 min)	1.35 [0.63, 2.90]	-	1 study	14,890	131	not evaluable	ROB	-
Low Apgar score (< 7) (at 5 min)	1.65 [0.72, 3.78]	-	1 study	1,722	131	not evaluable	ROB	-
Neonatal death (< 28 days of life)	2.83 [0.18, 45.47]	-	1 study	627	131	not evaluable	ROB	-
Neonatal disorders (as a whole)	2.14 [1.51, 3.04]	-	1 study	161,484	131	not evaluable	ROB	3.70 [2.38; .]
Neonatal medical care	0.87 [0.28, 2.73]	-	1 study	8,569	131	not evaluable	ROB	-
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Child/Infant death (> 28 days of life)	13.60 [0.84, 219.80]	-	1 study	130	131	not evaluable	ROB	-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
ASD (Autism spectrum disorder): Diagnosis	1.53 [0.73, 3.20]	-	1 study		451	not evaluable	ROB	-
ASD (Autism spectrum disorder): Diagnosis/Risk	1.53 [0.73, 3.20]	-	1 study		451	not evaluable	ROB	-
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