Dosulepin / Dothiepin updated on 07-01-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18164
R76395		 Chan (Controls exposed to SSRIs), 2024 Cardiac malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.46 [0.43;4.94] C
excluded (control group) 		3/83   24/956 27 83
ref
S18151
R76306		 Chan (Controls unexposed, general pop), 2024 Cardiac malformations 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.29 [0.72;7.25] 3/83   8,107/462,377 8,110 83
ref
Total 1 studies 2.29 [0.72;7.27] 8,110 83
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chan (Controls unexposed, general pop), 2024Chan, 2024 1 2.29[0.72; 7.25]8,110830%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.29[0.72; 7.27]8,11083 -NAChan (Controls unexposed, general pop), 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.29[0.72; 7.27]8,11083 -NAChan (Controls unexposed, general pop), 2024 1 Tags Adjustment   - Yes  - Yes 2.29[0.72; 7.27]8,11083 -NAChan (Controls unexposed, general pop), 2024 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.29[0.72; 7.27]8,11083 -NAChan (Controls unexposed, general pop), 2024 1 All studiesAll studies 2.29[0.72; 7.27]8,11083 -NAChan (Controls unexposed, general pop), 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18164

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.29[0.72; 7.27]8,11083 -NAChan (Controls unexposed, general pop), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.46[0.43; 4.94]2783 -NAChan (Controls exposed to SSRIs), 2024 10.510.01.0