Interferon beta 1b (IFN-beta1b) updated on 07-06-2020

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.71 [0.37, 7.96]0%2 studies5,00121not evaluable ROB-
Major congenital malformations1.88 [0.33, 10.69]0%2 studies4,99821not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.32 [0.31, 5.56]61%3 studies20668not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preeclampsia7.58 [1.10, 52.23]-1 study510not evaluable ROB14.65 [1.43; .]
Gestational diabetes1.32 [0.05, 34.93]-1 study110not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Jaundice / Icterus1.21 [0.14, 10.79]-1 study910not evaluable ROB-
Neonatal medical care10.44 [0.60, 181.46]-1 study210not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Child/Infant infections (> 1 year)2.00 [0.21, 19.05]-1 study610not evaluable ROB-
Child/Infant weight abnormalities (> 1 year)3.28 [0.12, 86.28]-1 study110not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)1.70 [0.43, 6.67]57%2 studies6470not evaluable ROB-
Elective/induced termination of pregnancy2.27 [0.76, 6.76]-1 study3152not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
ADHD (Attention deficit hyperactivity disorder): Diagnosis1.95 [0.09, 43.62]-1 study210not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk1.95 [0.09, 43.62]-1 study210not evaluable ROB-
Cognitive developmental disorders/delay (> 6 years old)1.95 [0.09, 43.62]-1 study210not evaluable ROB-
Language disorders/delay1.32 [0.05, 34.93]-1 study110not evaluable ROB-
Learning disorders 3.28 [0.12, 86.28]-1 study110not evaluable ROB-
Psychomotor developmental disorders/delay1.32 [0.05, 34.93]-1 study110not evaluable ROB-

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