metaPreg - Temazepam during pregnancy

Temazepam updated on 02-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
Congenital heart defects	1.96 [1.02, 3.79]	0%	2 studies	2,687	379	not evaluable	ROB	3.33 [1.14; .]
Oro-facial clefts	0.71 [0.04, 11.64]	-	1 study	35	379	not evaluable	ROB	-
Abdominal wall defects	12.69 [1.42, 113.82]	-	1 study	5	379	not evaluable	ROB	24.87 [2.18; .]
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.04 [0.47, 2.31]	-	1 study	529	379	not evaluable	ROB	-
Chromosomal abnormalities	0.78 [0.05, 12.74]	-	1 study	32	379	not evaluable	ROB	-
Digestive system anomalies	1.45 [0.09, 24.12]	-	1 study	17	379	not evaluable	ROB	-
Ear, face and neck anomalies	3.38 [0.19, 59.28]	-	1 study	7	379	not evaluable	ROB	-
Eye defects	1.30 [0.08, 21.55]	-	1 study	19	379	not evaluable	ROB	-
Genital anomalies	0.59 [0.08, 4.28]	-	1 study	86	379	not evaluable	ROB	-
Limb defects	0.66 [0.09, 4.73]	-	1 study	78	379	not evaluable	ROB	-
Major congenital malformations	1.04 [0.47, 2.31]	-	1 study	529	379	not evaluable	ROB	-
Nervous system anomalies	3.28 [0.78, 13.75]	-	1 study	33	379	not evaluable	ROB	-
Respiratory system anomalies	1.88 [0.11, 31.63]	-	1 study	13	379	not evaluable	ROB	-
Urinary malformations	0.84 [0.12, 6.10]	-	1 study	61	379	not evaluable	ROB	-
Cleft lip with or without cleft palate	-	-	0 study					-
Cleft palate	-	-	0 study					-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	2.74 [1.29, 5.83]	-	1 study	27,149	29	not evaluable	ROB	4.92 [1.90; .]
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