Nitrazepam (Psy and mixed indications) updated on 02-10-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)0.23 [0.03, 1.66]-1 study49,500134not evaluable ROB-
Cleft lip with or without cleft palate5.02 [0.24, 104.70]-1 study6302not evaluable ROB-
Cleft palate0.33 [0.01, 8.19]-1 study1791not evaluable ROB-
Major congenital malformations0.23 [0.03, 1.66]-1 study49,500134not evaluable ROB-
Ano-rectal atresia and stenosis--0 study-
Atresia or stenosis of other parts of small intestine--0 study-
Bilateral renal agenesis including Potter syndrome--0 study-
Club foot / Talipes equinovarus--0 study-
Congenital heart defects--0 study-
Ear malformations--0 study-
Eye defects--0 study-
Gastroschisis--0 study-
Genital anomalies--0 study-
Hydrocephaly--0 study-
Hypospadias--0 study-
Limb reduction defects (LRD)--0 study-
Microcephaly / Small head circumference for gestational age--0 study-
Neural Tube Defects--0 study-
Oesophageal atresia with or without tracheo-oesophageal fistula--0 study-
Polydactyly--0 study-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions1.65 [0.07, 40.48]-1 study27,1491not evaluable ROB-

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